Articles related to PRACTICE PEARLS

The timing of re-initiation of antithrombotic therapy needs to be individualized based on the severity of the bleed, among other factors. This article reviews the issue and offers tools and guidelines for determining if and when to restart antiplatelet and oral anticoagulant therapy.

Because many BP-I patients present with depressive rather than manic symptoms, if a careful evaluation for past manic episodes is missed, it can easily result in an incorrect diagnosis of MDD.

In addition to stroke, central causes of vertigo include brainstem glioma, medulloblastoma, vestibular schwannoma, and vestibular migraine. Peripheral causes include BPPV, Meniere disease, acute labyrinthitis, vestibular neuritis, and multiple sclerosis.

Relapsing MS treatment remains difficult, and new therapeutic targets have been investigated. S1P, a bioactive lysophospholipid signaling molecule present in several organs, including the central nervous system, is one such target. S1P plays a role in a variety of physiologic and pathophysiologic processes. S1P levels have been linked to disease progression in the brain parenchyma and cerebrospinal fluid of MS patients. There are 5 recognized S1PR subtypes, and depending on the receptor being targeted, their expression patterns and outcomes change. S1PRMs are a more recent class of RMS treatments, and the FDA has currently approved 4 of these treatments: fingolimod, siponimod, ozanimod, and ponesimod.

The pandemic forced hospitals to quickly become more flexible. They were challenged to find ways to invent new space for ICUs and ERs within existing facilities. Virtual critical care and virtual specialty care were implemented. Outside spaces were re-envisioned for clinical purposes and physicians and other HCPs were to reimage and expand care space within the hospital walls.

The study’s findings offer a novel perspective on norepinephrine reuptake inhibitors’ impact on “upper airway stability during sleep and are significant to guide future pharmacotherapy development for OSA,” according to the authors. Additionally, the findings offer individuals who are unable to tolerate modern therapies, such as continuous positive airway pressure (CPAP) equipment, wider alternatives when seeking therapy for OSA.