Early ovary removal may lead to abrupt endocrine dysfunction, potentially increasing the risk of cognitive impairment and dementia in women.

Sotorasib treatment in two patients with severe KRAS G12C-driven arteriovenous malformations resulted in rapid symptomatic improvement and sustained reduction in malformation volume over 24 months.

The addition of blinatumomab to consolidation chemotherapy in adults with MRD-negative B-cell precursor ALL demonstrated a significant improvement in overall survival. At 3 years, the overall survival rate was 85% in the blinatumomab group compared to 68% in the chemotherapy-only group.

PBMs’ vertical integration allows them to dictate cancer treatment decisions, from drug selection to delivery methods, potentially compromising patient care and increasing costs.

In a trial of 2,736 participants, nirmatrelvir-ritonavir given as postexposure prophylaxis for 5 or 10 days did not significantly reduce the risk of symptomatic SARS-CoV-2 infection compared to placebo among household contacts of COVID-19 patients.

The 2024-2025 cancer care rankings incorporate outpatient outcomes and refine criteria for high-risk patient transfers, aiming to provide a more comprehensive evaluation of cancer care quality.