When tested at 32 weeks gestation, fetuses whose mothers ate carrots reacted with smiles, while those whose mothers ate kale showed crying faces. And those reactions became more expressive as the fetuses mature.

This case-control study carried out at six hospitals between Oct 2021 and July 2022 found that boosters yielded a 75% reduction in COVID hospitalization risk in the first 50 days post-booster, declining to 25% reduction in hospitalization risk at over 150 days. Other factors associated with an increased odds of hospitalization for COVID-19 included age of 70 years or older, male sex, cognitive disease, COPD, diabetes, immunodeficiency, obesity, rheumatologic disease, transplant, and Pfizer-BioNTech vaccination.

In the 5-year, multi-center, randomized, controlled GRADE trial (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study), insulin glargine and liraglutide were about 13% more effective than glimepiride in keeping HbA1c lower than 7.0%, and 30% more effective than sitagliptin.

Patients discontinuing antidepressant therapy experience insomnia, flu-like symptoms, mood disturbances, dizziness, and paresthesias — among a broad array of adverse effects. Those symptoms can last for days to months. This narrative review describes the array of discontinuation symptoms and their causes and provides practical clinical guidance for discontinuing antidepressants to minimize the risk of antidepressant discontinuation syndrome (ADS).

Palliative care (PC) can help reduce emergency department use, hospitalizations, and symptom burden across a spectrum of diseases. To assist clinicians in keeping their expertise current, the authors reviewed and summarized the top PC articles of 2020. The analysis included 28 PC intervention trials for heart failure, chronic obstructive pulmonary disease, and dementia.

In the phase III trial for zuranolone, 67.4% of patients who received an initial 2-week course at the 30-mg dose level initially achieved a 50% or greater reduction from baseline on the HAMD-17. Over the following year, half of those patients required additional 2-week courses of therapy. Of the group who received the 50-mg dose, only 25% needed subsequent courses.