Articles related to CLINICAL STUDY

The University of Virginia researchers used healthy mice and mice genetically engineered to lack aryl hydrocarbon receptor (AHR) in CD4-positive T-cells, an immune cell type implicated in MS, in the first set of experiments. These animals were subjected to the standard protocol for inducing an MS-like disease called experimental autoimmune encephalomyelitis (EAE). The results showed that mice lacking AHR had the same time to disease onset and peak clinical severity as healthy mice, but recovered faster in the chronic phase. The difference in recovery was only observed when the mutant mice were housed separately from their healthy counterparts, according to the researchers. The team hypothesized that this was due to microbiome differences that were only apparent when the mice lived separately and did not influence each other’s microbiomes.

Multiple studies’ pooled data revealed a significantly increased risk of Parkinson’s when combined with bullous pemphigoid, a rare skin condition, inflammatory bowel disease (IBD), or Sjögren’s syndrome. Immune response impairment has been linked to Parkinson’s disease in a growing body of evidence. Indeed, some studies have suggested that the neurodegenerative disease may be exacerbated by autoimmune processes, which occur when the immune system incorrectly attacks and destroys healthy tissue.

The results of these trials show that vitamin D reduced the risk of diabetes progression by 3% to 18% after three years, with serum 25-hydroxy D levels of at least 125 nmol/L showing the greatest benefit. Vitamin D was also associated with a 30% increase in the likelihood of returning to normal glucose regulation.

This observational study compared IV ketamine (47) to IN esketamine (15) in 62 adults suffering treatment-resistant depression. Response was measured using the QIDS-SR tool. The results? The two formulations were comparable in terms of change between baseline and endpoint QIDS-SR and response rates. However, IV ketamine generated benefits with fewer treatments.

4,500 people were tracked using 24-hour monitors for 7 days. Activity levels were studied to determine the effect on short-term memory, problem-solving, and processing skills. As little as six to nine minutes of moderate-to-vigorous activity when compared to sitting, sleeping, or gentle activities yielded higher cognition scores. Cognitive improvement was modest, but increasing time spent in energetic activity increased the measured benefits.

A prospective cohort study of 629 patients with non-MRI-conditional ICDs from 2003 to 2013, including 813 MRIs, concludes that the devices continue to function properly after MRI.