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Elevated plasma Lp(a) concentrations were associated with a 41% faster progression of peak aortic jet velocity and a 57% faster progression of mean transvalvular gradient in patients with aortic stenosis.

Tenecteplase administered up to 24 hours after stroke onset improved functional outcomes in patients with large-vessel occlusion and salvageable brain tissue who lacked access to immediate thrombectomy.

Sotorasib treatment in two patients with severe KRAS G12C-driven arteriovenous malformations resulted in rapid symptomatic improvement and sustained reduction in malformation volume over 24 months.