This target trial emulation study provides critical insights into weight change associated with eight first-line antidepressants, emphasizing the minimal weight gain with bupropion. Clinicians should integrate these findings into treatment decisions to address patient concerns about weight gain.

Reflecting on a critical mistake, a senior resident learns the value of compassion and mentorship in navigating the challenges of medical errors. This narrative highlights the importance of open discussions in fostering professional growth.

High doses of loperamide, an OTC antidiarrheal, are being abused for opioid-like effects, leading to severe cardiac risks. Clinicians should screen for loperamide toxicity in patients with a history of opioid use presenting with related symptoms.

Clinicians should be vigilant about melatonin interactions with various medications such as antidepressants, blood thinners, and blood pressure drugs to ensure patient safety and effective treatment.

Dupilumab significantly induced histologic remission in 68% of children with eosinophilic esophagitis compared to 3% in the placebo group, according to a phase 3 trial.

A diet high in soluble fiber, protein, and healthy fats can mimic the effects of GLP-1 agonists like Ozempic, offering a safer alternative for weight management and metabolic health.