Articles related to METABOLIC DISORDERS

In the absence of contraindications, metformin should be seriously considered as an off-label initial therapy and as an adjunct to antiobesity medications approved by the US Food and Drug Administration.

A randomized controlled trial involving 108 adults with metabolic syndrome found that implementing an 8- to 10-hour time-restricted eating window, in addition to standard-of-care treatments, resulted in a 0.10% reduction in HbA1c levels compared to standard care alone.

A prospective study involving over 170,000 participants from the UK Biobank found that moderate coffee consumption (3 drinks/day) was associated with a 48.1% lower risk of developing cardiometabolic multimorbidity compared to non-consumers.

Intramuscular fat accumulation poses a significant mortality risk, potentially surpassing that of obesity and muscle wasting, according to recent research.

The 2023 PCOS guideline update strengthens the recognition of PCOS as a complex condition with far-reaching health implications, emphasizing the need for a multidisciplinary approach to care.

SGLT-2 inhibitors offer benefits beyond glucose control, potentially addressing the systemic inflammatory components of metabolic diseases like diabetes, heart failure, and gout.