Articles related to Surgical Oncology

A patient with advanced, treatment-resistant lung cancer experienced complete tumor disappearance after sodium selenite treatment and remained tumor-free for 10 years. The single case cannot establish efficacy, safety, or causality.

Daily low-dose endoxifen reduced mammographic breast density versus placebo in premenopausal women, with fewer tolerability concerns at 1 mg. Whether this surrogate response translates into lower breast cancer incidence remains unknown.

Emerging evidence suggests microbiome composition may be associated with immunotherapy response, toxicity, and outcomes in kidney cancer. Experts caution that inconsistent methodologies and limited reproducibility continue to challenge microbiome biomarker development.

A patient with obstructive jaundice and persistent suspicion for periampullary malignancy was ultimately found to have multifocal grade 1 pancreatic neuroendocrine tumors after surgical resection. The case highlights the diagnostic limitations of preoperative tissue sampling in selected periampullary lesions.

A phase 1 study of mKRAS-VAX in 20 patients at high risk for PDAC showed KRAS-specific T-cell responses in most participants. No high-grade adverse events occurred, but clinical prevention data remain early.

A Veterans Health Administration analysis of 4,890 men with metastatic hormone-sensitive prostate cancer found that achieving a PSA level below 0.2 ng/mL within 9 months was associated with improved survival. The retrospective findings support a threshold previously identified in clinical trials.