Articles related to ANTIPSYCHOTICS

This groundbreaking study from Northwestern Medicine unveils a surprising interaction of antipsychotic drugs with neurons, prompting a revision of our understanding of psychosis treatment and opening new pathways for more effective, safer drugs.

Study Reveals Different Effects of Antipsychotics on Weight Gain: Key Findings for Physicians A new study analyzed the impact of different antipsychotic medications on weight gain, emphasizing the importance of considering dose and specific drugs for individual patients. The study provides valuable insights for physicians to make informed decisions regarding antipsychotic use. Key Points: “Weight gain from medication is one of the most problematic adverse effects facing patients with serious mental illness… It can be a real barrier in getting people to take their meds.” Michel Sabé, MD, corresponding author

Understanding the Effects of Drugs with Depressive Symptom Side Effects on Patients with MDD Learn more about the complex interaction between the usage of specific drugs and the severity of depressive symptoms in people with major depressive disorder (MDD).

When atypical AMD is suspected, additional multimodal imaging and a more detailed medical history are required to establish the correct diagnosis. The medical history, clinical examination, and retinal imaging findings of a 69-year-old White man with a long-standing medical history of schizophrenia, bilateral visual decline, nyctalopia, and blurred vision were sufficient evidence for the doctors to establish a presumed diagnosis of thioridazine retinal toxicity. Although it is a rare diagnosis due to the introduction of newer medications, patients with an underlying psychiatric history and atypical retinal findings on examination may have been or are currently taking the culprit psychotropic medication.

Lumateperone 42 mg/d is effective in the treatment of schizophrenia and has no clinically significant effects on body weight, metabolic variables, motor function, the ECG QT interval, or prolactin levels, with a likelihood to be helped or harmed (LHH) much greater than 1 when comparing therapeutic response to these tolerability/safety outcomes. When comparing therapeutic response versus a somnolence/sedation AE, lumateperone appears to be associated with somnolence/sedation, and LHH approaches 1. In indirect comparisons with other antipsychotics, this somnolence/sedation AE profile is not dissimilar; however, the absence of weight gain, glucose/lipid abnormalities, and akathisia, as well as the absence of prolactin elevations, distinguishes lumateperone.

To sum up the reasons you should use caution: Quetiapine has a variety of effects, including sedation, influencing a number of central nervous system receptors. Quetiapine should only be used to treat insomnia in patients who also have co-occurring mood or schizophrenia spectrum disorders. Quetiapine is less frequently linked to extrapyramidal side effects and dystonia than many other antipsychotic medications, but it is more frequently linked to weight gain, metabolic syndrome, and QTc prolongation. Prior to beginning treatment and then on a frequent basis thereafter, measurements of body mass index, weight, blood pressure, fasting glucose, and lipid levels should be made, even at modest doses. Despite not producing euphoria, quetiapine is frequently misused to amplify or lessen the negative effects of illegal substances. For older patients, quetiapine has additional dangers.