Articles related to CLINICAL STUDY

Of the four most commonly prescribed antiepileptic drugs (AEDs) in the UK, carbamazepine wasn’t significantly associated with Parkinson’s, but three AEDs did have a significant relationship, including lamotrigine, levetiracetam, and sodium valproate.

This meticulous study shows that SARS-CoV-2 infection is systemic and involves many organ systems, including the brain. But are the findings relevant to today’s public? None of the patients had been vaccinated and all were older with significant comorbidities.

This 10-year study is the first large, population-based assessment of spasticity treatment in MS. It reveals that younger, newly diagnosed people are prescribed baclofen more their older peers. This is the first study to show high rates of baclofen discontinuation among all patients with MS, with more than 50% of patients discontinued treatment within 6 months.

Uterine fibroids are a common cause of heavy menstrual bleeding and pain. Combination therapy with once-daily oral gonadotropin-releasing hormone-receptor antagonist relugolix plus estradiol and norethindrone acetate in a 12-week course resulted in a significant reduction in bleeding in more than 70% of those in the therapy arms versus less than 20% for the placebo groups.

In the US, only two emergency contraceptive methods have been FDA approved: oral levonorgestrel and oral ulipristal acetate. However, the copper IUD appears to be an order of magnitude more effective than the approved methods and so copper IUD is often used. But women prefer the levonorgestrel IUD. This study looked to compare the two IUDs as emergency contraceptives. Among 711 women randomized to copper versus levonorgestrel IUDs, pregnancy rates were 1 in 317 in the levonorgestrel group and 0 in 321, equating to non-inferiority for the levonorgestrel IUD.

For the treatment of psychosis in schizophrenia, may an oral molecule constitute a new class of psychotropic drug with a non-D2-receptor binding mode of action? The purpose of a recent study was to answer that question, which Dr. Matt Birnholz delves into in this audio abstract.