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Cureus
Two long-term proton pump inhibitor users presented with severe macrocytic anemia, markedly elevated LDH, and low haptoglobin suggestive of hemolysis. Further evaluation identified combined vitamin B12 and folate deficiency, highlighting a diagnostic mimic of true hemolytic anemia.
Family Medicine/General Practice August 17th 2026
Psychiatrist.com
Chronic PPI use was associated with elevated dementia and mild cognitive impairment risk in older adults across pooled observational studies, though high heterogeneity and residual confounding leave causality unresolved.
Family Medicine/General Practice April 29th 2026
Gut
Lincosamides carried a 31-fold CDI risk and PPIs nearly doubled it in a Swedish analysis of 42,921 cases and 355,159 controls, with corticosteroids, antidepressants, and beta blockers also emerging as independent contributors.
Clinical Pharmacology April 27th 2026
Epoch Health
This review highlights the importance of evaluating the duration of proton pump inhibitor therapy in light of its association with an increased risk of stomach cancer. Long-term use, defined as one year or more, can significantly heighten this risk, emphasizing the need for judicious use of these medications.
Oncology, Medical April 15th 2024
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