Articles related to THYROID CANCER

A reflective case study highlights this author’s take on papillary thyroid cancer, which has high survivability but cannot be considered “good.” Telling patients they have good cancer is dismissive and minimizes the patient experience associated with this diagnosis. When caring for patients with papillary thyroid cancer, this commonly used statement is contradictory. Providers of all specialties must consider the psychological and physiological effects that papillary thyroid cancer has on patients. It is critical to practice improving news delivery through effective and empathetic communication.

Looking at 2,500 case patients mapped to more than 45,000 controls, the hazard ratio for all thyroid cancers in GLP-1 users was 1.46. The hazard ratio for developing thyroid cancer with DPP-4 inhibitors was 1.1. GLP-1 receptors are present in normal and cancerous thyroid cells.

With just a few exceptions (p.I157T, p.S428F, and p.T476M), CHEK2 PVs were linked to comparable cancer phenotypes regardless of the variation type. Although CHEK2 PVs were linked to breast, kidney, and thyroid malignancies, they were not linked to colorectal cancer. The prevalent p.I157T, p.S428F, and p.T476M alleles have a weaker connection with breast cancer compared to other CHEK2 PVs and were not related with non-breast malignancies. These findings might help with genetic counseling and care for those with CHEK2 PVs.

In the study,155 FDA-approved drugs with 136 potentially targetable genes were identified.One-hundred forty-six (94%) of the drugs showed no or low genetically predicted drug response. Although ATC-carrying BRAF mutations can benefit from BRAF inhibitors and this effect might be enhanced by a combined strategy including PIK3CA inhibitors in some of the patients, alterations in BRAFWT ATC are not directly targeted by currently FDA-approved options.

These authors found a “consistent positive association between pre-existing thyroid autoimmunity and higher thyroid cancer risk.” There also appears to be a correlation between thyroid antibody levels and related risk. The association appeared stronger in women than in men. The authors do not recommend screening for thyroid cancer in those with thyroid autoimmunity because of the risk of overdiagnosis.