Menin inhibitors, targeting the menin-KMT2A interaction, have demonstrated significant response rates in treating specific genotypes of AML and ALL, offering a new avenue for personalized leukemia therapy.

Lower baseline testosterone and hormonal imbalances, including low SHBG and DHT levels, are significantly associated with increased all-cause and cardiovascular mortality in aging men.

A large-scale randomized controlled trial has identified significant prognostic factors for overall survival (OS) and cancer-specific survival (CSS) in localized prostate cancer, offering new insights into optimizing treatment strategies using surgery and radiotherapy.

The Medscape Women Physicians Report 2020 reveals that 64% of female physicians prioritize work-life balance, often feeling conflicted between their careers and caregiving responsibilities, necessitating flexible work arrangements and supportive policies.

Should interns visit patients early in the morning or wait to see them during rounds? This article examines the impact of prerounding on intern autonomy, learning, and patient care.

The study found that andexanet alfa significantly improves hemostatic efficacy in patients with intracerebral hemorrhage on factor Xa inhibitors but increases the risk of thrombotic events. These findings highlight the need for careful patient selection and monitoring when considering andexanet alfa in clinical practice.