This study reports long term outcomes on CALGB 40603 at a median follow-up of 7.9 years. Event-free survival and other LTOs were not significantly improved with either study drug overall or in studied sub-populations. Results showed that patients with any residual disease had significantly worse outcomes. This finding supports considering adjuvant therapy even in the setting of minimal residual disease.

This update of the GO29365 study shows significant survival benefit with pola + BR vs BR alone in R/R, transplant ineligible DLBCL. In the randomization arms, median progression-free survival was 9.2 vs 3.7 months and median overall survival was 12.4 vs 4.7 months for the pola + BR arm vs the BR arm. In the extension cohort, the OR rate was 41.5%, and the CR rate was 38.7%; PFS and OS were 6.6 months and 12.5 months, respectively.

Can you figure out the cause of this progressing discoloration on the bilateral anterior thighs of this 48-year-old patient? The patient denies pain, itching, or blistering, but her medical history is relevant for hypothyroidism. Any guesses?

Just because they are highly educated and high-income earners does not mean physicians are immune from making bad financial decisions. Poor investment decisions, failure to plan for taxes, and escalating debt loads are just a few of the financial issues that plague doctors across the US.

In contradistinction to recent reports that showed increased risk of death and no clinical benefit with escalation of allopurinol for progressive CKD, this 5-year population-based review found no increased mortality risk in escalating allopurinol dose and achieving target serum urate levels.

Vitamin D supplementation for five years, with or without omega-3 fatty acids, reduced autoimmune diseases such as rheumatoid arthritis and psoriasis by 22%, according to the findings of a new study published in the British Medical Journal (BMJ). Omega-3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15%, which was not statistically significant. Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega-3 fatty acid placebo).