Articles related to RESEARCH & CLINICAL TRIALS

Actigraphy devices revealed significant improvements in sleep patterns with nighttime levodopa use, despite patients not perceiving these changes subjectively.

Recent studies have identified a range of chemical compounds released by face masks, including microplastics, volatile organic compounds, and plasticizers, prompting a closer examination of potential cumulative exposure risks.

A recent study involving 20,440 older adults with kidney failure found that initiating dialysis at an eGFR below 12 mL/min/1.73 m2 resulted in a mean survival of 770 days over a 3-year period, compared to 761 days for those continuing medical management

The combination of ponatinib and blinatumomab demonstrated a 95% complete response rate and 91% 3-year overall survival rate in patients with Ph-positive ALL.

The I-SPY2 trial demonstrates that novel treatment approaches can yield high pathologic complete response rates in rare histologic subtypes of high-risk breast cancer, potentially improving outcomes for these challenging cases.

Valoctocogene roxaparvovec gene therapy demonstrates long-term efficacy in reducing bleeding episodes and factor VIII use in patients with severe hemophilia A, potentially changing the treatment landscape for this condition.