Thinking of starting the new year off with a diet? According to U.S. News and World Report, the Mediterranean diet is the best overall diet for adults. The diet was ranked first in the categories of best diets for healthy eating, easiest diets to follow, and best diets for diabetes, among other measurable categories.

A new study has found that people with osteoporosis may experience less protection and be subject to more bone fractures when treated with the drug risedronate. Patients who were treated with risedronate during a drug holiday experienced more hip and other fractures than patients given other medications. Drug holidays are recommended after three to five years on therapy for most people taking bisphosphonates for osteoporosis. Risedronate, with its shorter half-life compared with alendronate, is associated with a somewhat higher risk of hip fracture during a drug holiday.

Orexin receptor antagonists work by suppressing the wake drive through blocking wake-promoting neuropeptides. Daridorexant is the third dual-orexin inhibitor to receive FDA approval for people with difficulty in sleep onset or sleep maintenance.

Illucix is a preparation kit for gallium-68 PSMA-11 injection, an agent indicated for PET PSMA position tumors in patients with suspected prostate cancer metastasis who are eligible for initial definitive therapy and have suspected cancer recurrence based on elevated PSA levels.

A JAMA Oncology study of nearly 480,000 patients found immune-mediated diseases are associated with a greater risk of cancer at the local and systemic levels. The findings support the role of local and systemic immunoregulation in carcinogenesis and could lead to a new way of viewing immune-mediated diseases.

The authors of this JCO study used a PET-adaptive approach to reduce the need for radiotherapy (RT) in early PET (-) disease and escalate therapy in patients with PET (+) disease. The study reports excellent outcomes for the approach, which allowed omission of radiotherapy in more than three-quarters of patients.