In a large multinational target-trial emulation, adults with serious mental illness who initiated GLP-1 receptor agonists experienced lower mortality and cardiovascular event rates than matched patients initiating SGLT2 inhibitors, though residual confounding remains a key limitation.

A single-day inhaled mebufotenin regimen produced rapid, sustained symptom reductions through day 8 in 10 patients with postpartum depression, but the uncontrolled trial provides an early clinical signal rather than comparative efficacy evidence.

Magnetoencephalography-based analysis of 263 patients with major depressive disorder identified five distinct brain connectivity profiles, each associated with differing symptom patterns, supporting the view that depression may encompass biologically heterogeneous subgroups rather than a single neurobiological condition.

In a French retrospective cohort, infants with Ewing sarcoma had favorable long-term survival after age-adjusted chemotherapy and predominantly surgical local control, although the 17-patient sample limits conclusions about treatment intensity and late toxicity.

Children exposed to maternal Tdap vaccination had lower pertussis toxin and diphtheria antibody concentrations at ages 3 and 4, but their responses matched controls after a preschool DTaP booster in this small Finnish follow-up.

Six major US hospital systems have entered DOJ settlements involving pediatric gender-affirming care, resulting in service restrictions for patients under 19 and highlighting how federal enforcement activity can influence healthcare access beyond states with formal bans.