Articles related to Cardiology

Statin exposure in LPS-primed mouse muscle cells activated NLRP3 inflammasome signaling and reduced protein prenylation, producing atrophy markers and grip strength loss in a preclinical model of statin myopathy.

The American College of Physicians issued a living clinical guideline recommending semaglutide and tirzepatide as first-line pharmacologic treatments with lifestyle modifications for nonpregnant adults with obesity (BMI 30 kg/m2 or higher) or overweight (BMI 27 to 30 kg/m2) with at least one weight-related comorbidity, with phentermine-topiramate, liraglutide, and naltrexone-bupropion designated as second-, third-, and fourth-line options respectively based on GRADE evidence review.

Celebrity disclosures about using beta blockers for performance anxiety are prompting patient questions in primary care, reviving a decades-old off-label use with a comparatively lower risk profile than benzodiazepines.

Several recent studies link daily avocado consumption to lower dietary glycemic load, reduced diabetes risk in women, and modest blood pressure improvements in prediabetes patients, though small sample sizes and short follow-up periods limit the conclusions.

A 31,000-patient observational study found that dihydropyridine calcium-channel blockers were associated with a 33% higher risk of major adverse kidney events in type 2 diabetes patients already on RASi and SGLT2i therapy.

A man in his early 30s presenting with post-viral chest pain and bilateral forearm numbness posed a diagnostic challenge when automated ECG interpretation missed findings later consistent with acute pericarditis, including diffuse concave-upward ST elevation, PR depression, and a positive Spodick sign.