Articles related to DRUG SAFETY & INTERACTIONS

A network meta-analysis of 716 randomized trials and 159,362 participants found ARB-based regimens had the lowest rates of treatment discontinuation due to adverse effects, with the ARB-CCB combination ranking as the best-tolerated dual-drug option among antihypertensive regimens examined.

Vitreoretinal surgeons describe off-label fibrin glue application as a localized tamponade alternative for rhegmatogenous retinal detachment repair, hemorrhage control, and retinal edge stabilization in cases where gas or silicone oil poses prohibitive patient or logistical constraints.

A systematic review of 43 randomized controlled trials found high-certainty evidence that multiple CGRP-targeted therapies reduced monthly migraine headache days by approximately 2 days versus placebo in adults with chronic migraine.

A two-sample analysis of GWAS data identified genetically predicted associations between six commonly prescribed medications and increased erectile dysfunction risk, while aspirin did not reach statistical significance after SNP exclusions.

A retrospective analysis of FDA postmarketing reports identified textural changes, pigmentary alteration, and subcutaneous fat loss as the most frequently reported adverse events following radiofrequency microneedling, with most cases occurring on the face and submental area.

Cotrimoxazole was associated with nearly twice the adverse event rate of fluoroquinolones in a retrospective study of 228 hospitalized men aged 75 or older with urinary tract infections, with acute kidney injury onset occurring at a median of six days post-initiation.