Articles related to EVIDENCE-BASED MEDICINE

The 2026 KDIGO anemia in CKD guideline replaces two long-standing iron deficiency classifications, endorses proactive high-dose IV iron in maintenance hemodialysis, and provides first-ever positioning guidance on HIF-PHIs, 14 years after the previous version.

A decade after surgery, patients who got their torn meniscus trimmed fared worse than those who received a sham procedure. The sham group reported less pain, more knee use, and less arthritis progression.

The American College of Physicians Performance Measurement Committee reviewed the single MIPS quality measure tied to migraine and declined to support it, citing outdated guideline basis, missing exclusions, and lack of physician-level testing.

Algorithm-guided treatment was associated with improved remission rates in 5 of 7 randomized trials of major depressive disorder, though heterogeneity in protocols and outcome measures limited direct comparability.

Rich in Igs, lactoferrin, cytokines, and growth factors, it can bolster innate and adaptive responses, reinforce gut barrier integrity, and promote repair after stressors such as strenuous exercise, medication injury, or surgery.

Muscle cramps are common in the general population, with reported prevalences ranging from 37% to 95%. When frequent or severe, muscle cramps can cause prolonged postcramp soreness and can diminish quality of life by disrupting sleep, limiting physical activity, and provoking anxiety about symptom recurrence.