Articles related to Psychiatry

Bupropion inhibits cytochrome P450 2D6,5 which is the enzyme that converts venlafaxine into an active metabolite, desvenlafaxine. When CYP2D6 is inhibited, venlafaxine levels rise at the expense of desvenlafaxine. Because the renal excretion of venlafaxine is small, the consequence is increased dose-dependent venlafaxine-related adverse effects.

Teva Pharmaceuticals is the primary supplier of both branded and generic versions of the stimulant, which is approved to treat ADHD and narcolepsy. Teva has cited increased demand, workforce shortages, and manufacturing disruptions due to packaging constraints as reasons for the supply problems.

In this meta-analysis including 340 patients across six clinical trials, ECT was more effective than ketamine in treating depression. There were no identified differences between the groups in terms of cognition, memory, or serious adverse events.

Prior research has revealed a potential link between damage to specific parts of the brain and repetitive addictive behaviors. In this report, with findings published in Nature Medicine, the investigators found that lesions that disrupted smoking and alcohol addiction behaviors occurred in many different brain locations and were characterized by a specific pattern of brain connectivity.

In this multicenter study, adult patients with status epilepticus were randomized into levetiracetam (LEV) or fosphenytoin (FPHT) as a second-line treatment after diazepam. The authors conclude that LEV may be recommended as a second-line treatment for SE along with phenytoin/FPHT.

Although results of meta-analyses on the link between vitamin D and depression have historically been mixed, emerging research suggests vitamin D supplementation may help with depression in certain populations. For example, revisiting prior meta analyses, investigators have found that vitamin D supplementation decreased depressive symptoms in MDD patients, as well as in women with perinatal depressive symptoms.