Articles related to Psychiatry

Among adults with both sleep disturbances and mild cognitive impairment, self-reported vitamin D supplementation of at least 5,000 IU daily was associated with higher cognitive assessment scores in a small observational study, while lower doses showed no similar association.

Childhood trauma was associated with altered hippocampal reward-pathway connectivity and greater adult anhedonia in a large neuroimaging cohort. The findings identify a potential neurobiological link but did not establish causality.

In a phase 3 trial of 214 adults with generalized anxiety disorder, a single dose of DT120 orally disintegrating tablets produced greater reductions in anxiety scores than placebo through 12 weeks. Full peer-reviewed data and longer-term results remain pending.

A post hoc analysis of five brexpiprazole trials found improved functioning in adults with schizophrenia, including those with baseline hostility or agitation. The exploratory findings require interpretation alongside trial-design limitations and lack of multiplicity adjustment.

Emerging reports suggest some patients experience emotional blunting or reduced reward responsiveness after starting GLP-1 receptor agonists. Current evidence remains mixed, and available data have not established a causal relationship between GLP-1 therapy and diminished antidepressant response.

A meta-analysis of seven studies found cannabinoid-based therapies were associated with lower agitation and neuropsychiatric symptom scores in patients with moderate to severe Alzheimer disease. Cognitive benefits were not consistently observed, and somnolence occurred more frequently with treatment.