Articles related to Psychiatry

In a large multinational target-trial emulation, adults with serious mental illness who initiated GLP-1 receptor agonists experienced lower mortality and cardiovascular event rates than matched patients initiating SGLT2 inhibitors, though residual confounding remains a key limitation.

A single-day inhaled mebufotenin regimen produced rapid, sustained symptom reductions through day 8 in 10 patients with postpartum depression, but the uncontrolled trial provides an early clinical signal rather than comparative efficacy evidence.

Magnetoencephalography-based analysis of 263 patients with major depressive disorder identified five distinct brain connectivity profiles, each associated with differing symptom patterns, supporting the view that depression may encompass biologically heterogeneous subgroups rather than a single neurobiological condition.

Research examining cannabis and sexual function suggests possible associations with increased sexual frequency and orgasm satisfaction in some users, but findings remain inconsistent, largely observational, and influenced by dose, timing, formulation, and individual factors.

Semaglutide use was associated with lower psychiatric hospitalization and bipolar-relapse hospitalization risks among Swedish adults with bipolar disorder receiving antidiabetic medication, although the observational findings did not establish a therapeutic effect.

The FDA granted Breakthrough Therapy designation to DT120, an oral lysergide formulation under investigation for major depressive disorder, based on phase 3 findings suggesting rapid and sustained antidepressant effects, though the treatment remains investigational and unapproved.