Articles related to BENZODIAZEPINES

First-trimester benzodiazepine exposure was not associated with a meaningful increase in major congenital malformations in a large US cohort study, although findings related to coexposure with other psychoactive medications remained inconsistent and require further investigation.

In a single-center randomized trial, mouth-dissolving clobazam and intranasal midazolam showed no statistically significant difference in clinical or electrographic seizure-termination time, supporting further study rather than establishing comparable efficacy.

Benzodiazepine use among U.S. adults aged 65 years and older declined before 2020 but remained largely unchanged through 2024. Long-term use persisted in roughly one-third of users, with smaller reductions among adults aged 75 years and older.

Short-term benzodiazepine use after mass trauma was not associated with increased 12-month PTSD risk in a large retrospective cohort. Persistent use showed a different pattern, and the observational findings did not establish causality.

Sedative-hypnotic drug effects vary with meal timing, metabolism, and drug half-life in patients with insomnia. These pharmacologic factors influence sleep onset and maintenance, particularly in patients with psychiatric comorbidities requiring concurrent medications.

Celebrity disclosures about using beta blockers for performance anxiety are prompting patient questions in primary care, reviving a decades-old off-label use with a comparatively lower risk profile than benzodiazepines.