Articles related to Family Medicine/General Practice

Nearly 89% of U.S. ischemic heart disease deaths in 2023 were attributable to modifiable risk factors, according to Global Burden of Disease data. Mortality rates declined substantially since 1990, although deaths linked to elevated BMI and fasting glucose increased.

A prototype wearable ring continuously monitored multiple sweat biomarkers, including glucose and ketones, in healthy volunteers and individuals with type 1 diabetes. The device’s readings tracked established monitoring technologies, though larger validation studies remain necessary.

The FDA approved enlicitide (Lipfendra), the first oral PCSK9 inhibitor for lowering LDL cholesterol in adults with hypercholesterolemia. Approval was based on substantial LDL-C reductions, while cardiovascular outcomes data remain pending.

Filtered coffee consumption was associated with lower biological age-acceleration measures in nearly 50,000 UK Biobank participants, while instant coffee showed the opposite pattern. The cross-sectional analysis did not establish causality and remains hypothesis-generating.

An observational study associated repeated gabapentin prescribing with higher rates of dementia and mild cognitive impairment, particularly among adults aged 18 to 64 years. Experts emphasized that the findings do not establish causality and should be interpreted cautiously.

A national analysis found that clinical obesity was present in more than one-quarter of adults with normal BMI values. The findings highlight limitations of BMI alone for identifying excess adiposity and obesity-related health risk.