Articles related to Gastroenterology

A 55-year-old man with bilateral hand arthritis, ruddy complexion, and elevated transferrin saturation presents a diagnostic reasoning challenge with implications for screening, surveillance, and family testing.

Chronic PPI use was associated with elevated dementia and mild cognitive impairment risk in older adults across pooled observational studies, though high heterogeneity and residual confounding leave causality unresolved.

TNF-alpha inhibitor exposure was associated with adjusted hazard ratios of 1.99 for basal cell carcinoma, 1.69 for squamous cell carcinoma, and 1.54 for melanoma in a 56,209-patient retrospective cohort.

Daraxonrasib produced 13.2-month median overall survival versus 6.7 months with chemotherapy in 501 previously treated metastatic pancreatic ductal adenocarcinoma patients in the phase 3 RASolute 302 trial.

Lincosamides carried a 31-fold CDI risk and PPIs nearly doubled it in a Swedish analysis of 42,921 cases and 355,159 controls, with corticosteroids, antidepressants, and beta blockers also emerging as independent contributors.

Emerging research suggests vitamin D may influence immune tolerance and gut interactions in IBD, though findings remain exploratory and adjunctive.