Articles related to Gastroenterology

The FDA has begun reviewing generic tirzepatide applications as global competition accelerates, despite US patent protections limiting near-term availability.

A multi-fiber formulation improved bowel frequency and stool consistency in adults with functional constipation in a short-term study evaluating combined fiber mechanisms.

The FDA approved olezarsen (Tryngolza), an apoC-III antisense inhibitor, as an adjunct to diet for reducing triglycerides and acute pancreatitis risk in adults with severe hypertriglyceridemia, based on phase 3 data showing an 85% reduction in pancreatitis events compared with placebo.

The American Cancer Society updated its colorectal cancer screening guidelines to include two new multitarget stool tests and a blood-based option, while maintaining colonoscopy as the gold standard and the age-45 screening initiation recommendation for average-risk adults.

In a 794-patient randomized trial, early-stage type 2 diabetes patients uncontrolled on metformin who received tirzepatide achieved nearly twice the HbA1c reduction of those on intensified conventional care at 2 years, and 60% reached normoglycemia (HbA1c <5.7%), compared to 24% in the ICC arm.

An Oregon gastroenterology group was hit with a $25M wrongful death verdict after a 43-year-old patient with obesity, obstructive sleep apnea, and hypertension died during a routine outpatient colonoscopy, with liability centered on the decision to perform the procedure in a lower-acuity setting despite a risk profile that plaintiffs argued warranted a hospital environment.