Articles related to Gastroenterology

Two Lilly-sponsored placebo-controlled trials found that adults who transitioned from high-dose injectable GLP-1 therapy to either oral tirzepatide (Foundayo) or a reduced 5 mg tirzepatide maintenance dose preserved most of their prior weight loss over one year, compared to substantial regain in placebo arms.

A narrative review of UCLA spice research found associations between common culinary spices — cinnamon, turmeric, red pepper, and spice blends — and glucose regulation, gut microbiome composition, and cognitive markers, though most findings stem from small trials and in vitro work using supratherapeutic doses.

A 21-element enhanced recovery protocol implemented across 18 US hospitals reduced inpatient opioid use by 56% in children undergoing GI surgery, with patients receiving 13 or more protocol elements averaging one fewer hospital day and half the complication risk.

After 23 years, men offered once-only sigmoidoscopy had 1.7 fewer colorectal cancers and 0.8 fewer CRC deaths per 100. In women, the mortality benefit didn’t reach significance.

Bariatric surgery volumes peaked in 2022 and have fallen since, with sleeve gastrectomy losing ground and Roux-en-Y conversions climbing as GLP-1 prescriptions expand.

A pediatric gastroenterology expert outlines when extrapolation of adult IBD therapies to children is reasonable, where it falls short, and how shared decision-making should be structured.