Articles related to MEDICAL DIAGNOSTICS

The revised McDonald criteria recognize the cerebrospinal fluid κFLC index as an alternative to oligoclonal bands for demonstrating intrathecal immunoglobulin synthesis, expanding laboratory options while preserving the need for integrated MS diagnosis.

Among newly diagnosed, treatment-naive patients with multiple sclerosis, gut microbiome profiles differed from healthy controls and were associated with MRI features linked to poorer prognosis, suggesting a potential future role for microbiome-based risk stratification.

A systematic review of reported vision loss cases following nonsurgical rhinoplasty found that visual impairment was typically immediate and often irreversible despite treatment. The findings highlight a rare but severe complication associated with cosmetic dermal filler injections.

Muscle ultrasound measurements obtained before and after exercise distinguished patients with generalized myasthenia gravis from healthy controls in a small case-control study, suggesting a potential imaging approach for assessing fatigability.

A 55-year-old man developed progressive weakness, areflexia, and respiratory compromise after a fall, despite spinal imaging that initially appeared to explain his presentation.

Baseline activity in the left dorsolateral prefrontal cortex and right precuneus during working memory and emotion-regulation tasks was associated with depression severity one year later in young adults at elevated risk for affective disorders, but not with future mania symptoms.