Articles related to Physical Medicine & Rehabilitation

A network meta-analysis found that long-term vitamin D supplementation added to standard multiple sclerosis therapy was associated with reduced relapse risk and improved disability outcomes.

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

A joint epilepsy society position statement endorsed validated noninvasive seizure detection and alerting devices as part of individualized epilepsy care while emphasizing their strongest performance in tonic-clonic seizures and the absence of proven SUDEP prevention.

PrimeC lowered neuron-derived TDP-43 levels in a Phase 2b ALS trial, with earlier analyses reporting functional and survival signals requiring confirmation in a planned pivotal study.

Differences in cerebrospinal fluid proteins distinguished women with multiple sclerosis from age-matched controls in a small exploratory study, highlighting potential hormonal and immune-related biological mechanisms. Findings require validation in larger populations before clinical application.

A decade after surgery, patients who got their torn meniscus trimmed fared worse than those who received a sham procedure. The sham group reported less pain, more knee use, and less arthritis progression.