Articles related to Physical Medicine & Rehabilitation

A novel small molecule, CN045, promoted oligodendrocyte maturation and modest remyelination in preclinical models of multiple sclerosis. The findings support an emerging strategy aimed at repairing damaged myelin, though clinical applicability remains unproven.

Fluvoxamine reduced fatigue and improved quality-of-life measures in adults with long COVID in a randomized placebo-controlled trial. The findings provide evidence for a potential therapy, although further research is needed to define optimal patient selection and treatment strategies.

A network meta-analysis found that long-term vitamin D supplementation added to standard multiple sclerosis therapy was associated with reduced relapse risk and improved disability outcomes.

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

A joint epilepsy society position statement endorsed validated noninvasive seizure detection and alerting devices as part of individualized epilepsy care while emphasizing their strongest performance in tonic-clonic seizures and the absence of proven SUDEP prevention.

PrimeC lowered neuron-derived TDP-43 levels in a Phase 2b ALS trial, with earlier analyses reporting functional and survival signals requiring confirmation in a planned pivotal study.