Articles related to COGNITIVE HEALTH/MEMORY

Accelerometer-derived sleep-wake cycle metrics independently predicted incident dementia in 53,448 UK Biobank participants, with predictive improvement comparable to APOE genotype contribution when added to age-only models.

Brain-predicted age difference and socioeconomic status moderated the relationship between AD pathology markers and cognitive performance in a cross-sectional cohort of 621 cognitively unimpaired older adults.

Baseline cognitive performance predicted future depression risk in opposite directions depending on depression history: lower cognition signaled higher risk in never-depressed controls, while higher cognition was associated with greater relapse risk in remitted depression, in a longitudinal UK Biobank analysis of 3,724 participants.

A narrative review of UCLA spice research found associations between common culinary spices — cinnamon, turmeric, red pepper, and spice blends — and glucose regulation, gut microbiome composition, and cognitive markers, though most findings stem from small trials and in vitro work using supratherapeutic doses.

A machine learning sleep EEG score measured in midlife was associated with neuropsychological performance over a decade later in a Framingham cohort.

Blarcamesine (Anavex 2-73), an investigational once-daily oral autophagy enhancer, showed sustained cognitive, functional, and brain volume benefits through nearly 3 years in a Phase 2b/3 trial and open-label extension presented at AD/PD 2026.