Articles related to Family Medicine/General Practice

A 4-week randomized trial in 20 obese men with hypercholesterolemia found that intermittent hypoxic training combined with caloric restriction produced greater reductions in LDL-C, total cholesterol, and triglycerides compared with normoxic training under identical dietary conditions.

A Bayesian network meta-analysis of 31 randomized trials found aerobic, combined, and high-intensity interval training each associated with reductions in 24-hour ambulatory systolic blood pressure compared with control conditions, with no modality demonstrating clear superiority and all comparisons rated very low to low confidence.

Among nearly 450,000 Scottish adults with hypertension, participants using a digital home blood pressure telemonitoring system showed lower rates of cardiovascular events, hospitalizations, and death compared with those receiving standard care over a median observation period spanning 2019 to 2022.

The American College of Physicians issued a living clinical guideline recommending semaglutide and tirzepatide as first-line pharmacologic treatments with lifestyle modifications for nonpregnant adults with obesity (BMI 30 kg/m2 or higher) or overweight (BMI 27 to 30 kg/m2) with at least one weight-related comorbidity, with phentermine-topiramate, liraglutide, and naltrexone-bupropion designated as second-, third-, and fourth-line options respectively based on GRADE evidence review.

Glucosamine use was associated with a 25% increase in mortality risk in patients with Alzheimer’s disease-related dementia in a retrospective analysis of more than 50,000 patients, with no corresponding signal observed in those with mild cognitive impairment.

Suicide mortality increased among adolescents and young adults across the Americas from 2000 to 2021. Rates varied by age, sex, and region, with widening disparities observed in population-level data.